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Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 143-151 doi: 10.1007/s11684-016-0451-1

Abstract:

Hair cells regenerate throughout the lifetime of non-mammalian vertebrates, allowing these animalsSince Forge and Warchol discovered the limited spontaneous regeneration of vestibular hair cells afterefforts have been exerted to trace the origin of the limited vestibular regeneration in mammals after hairFurthermore, this review highlights the current limitations of hair cell regeneration and provides thepossible solutions to regenerate functional hair cells and to partially restore vestibular function.

Keywords： utricle     hair cell     regeneration     Atoh1     Notch     Wnt    

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Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 178-190 doi: 10.1007/s11684-017-0507-x

Abstract:

Zebrafish is an emerging animal model for studies on auditory system. This model presents high comparability with humans, good accessibility to the hearing organ, and high throughput capacity. To better utilize this animal model, methodologies need to be used to quantify the hearing function of the zebrafish. Zebrafish displays a series of innate and robust behavior related to its auditory function. Here, we reviewed the advantage of using zebrafish in auditory research and then introduced three behavioral tests, as follows: the startle response, the vestibular-ocular reflex, and rheotaxis. These tests are discussed in terms of their physiological characteristics, up-to-date technical development, and apparatus description. Test limitation and areas to improve are also introduced. Finally, we revealed the feasibility of these applications in zebrafish behavioral assessment and their potential in the high-throughput screening on hearing-related genes and drugs.

Keywords： zebrafish (Danio rerio)     behavior     auditory     startle response     vestibular-ocular reflex     rheotaxis    

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MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Frontiers of Agricultural Science and Engineering 2016, Volume 3, Issue 1,   Pages 72-80 doi: 10.15302/J-FASE-2016089

Abstract: Previous studies have indicated that miRNAs are important for hair follicle development and growth.significantly upregulated in sheep wool follicle bulbs in anagen phase compared with the telogen phase of the hairFurthermore, transcript factor nuclear factor of activated T cells type 5 ( ) and were predicted tocould activate the Wnt/β-catenin signal pathway by targeting to promote the proliferation of human hairfollicle cells.

Keywords： miR-148b     hair follicle     proliferation     NFAT5     Wnt10b    

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Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 481-489 doi: 10.1007/s11684-016-0494-3

Abstract:  CKO mice) were generated using Pax2-Cre mice to investigate the function of LKB1 in inner ear haircells during early embryonic period.cells.LKB1 deficiency in LKB1Pax2 CKO mice thus disrupted hair cell planar polarity duringOur results suggest that LKB1 is required in PCP formation in cochlear hair cells in mice.

Keywords： LKB1     stereociliary bundles     kinocilium     planar cell polarity     hearing     mice    

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Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear haircells

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 637-650 doi: 10.1007/s11684-021-0864-3

Abstract: anticancer, anti-inflammatory, and antioxidant activities, on neomycin-induced ototoxicity in cochlear haircells in vitro.Results showed that apigenin significantly ameliorated the loss of hair cells and the accumulation ofcells.This study provided evidence of the protective effect of apigenin on cochlear hair cells and its underlying

Keywords： apigenin     aminoglycosides     ototoxicity     oxidative stress     Nrf2 signaling pathway    

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Alternative splicing of inner-ear-expressed genes

Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 250-257 doi: 10.1007/s11684-016-0454-y

Abstract: inner-ear-specific alternative splicing, and as a result, Cdh23(+68) is only expressed in inner ear haircells.

Keywords： alternative splicing     inner ear     hearing loss     hair cells    

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is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice

Yuqin Men, Xiujuan Li, Hailong Tu, Aizhen Zhang, Xiaolong Fu, Zhishuo Wang, Yecheng Jin, Congzhe Hou, Tingting Zhang, Sen Zhang, Yichen Zhou, Boqin Li, Jianfeng Li, Xiaoyang Sun, Haibo Wang, Jiangang Gao

Frontiers of Medicine 2019, Volume 13, Issue 6,   Pages 690-704 doi: 10.1007/s11684-018-0638-8

Abstract: encodes the taperin protein, which is concentrated in the tapered region of hair cell stereocilia inWe observed significant hearing loss and progressive degeneration of stereocilia in the outer hair cells

Keywords： TPRN     stereocilia     stereociliary rootlet     actin filament     CRISPR/Cas9     hearing    

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Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 237-249 doi: 10.1007/s11684-016-0464-9

Abstract:

Sensory hair cells in the inner ear are responsible for sound recognition.Damage to hair cells in adult mammals causes permanent hearing impairment because these cells cannotcells.Both signaling pathways allow resident supporting cells to regenerate hair cells in the neonatal cochleacell fate determiner Atoh1 to regulate hair cell regeneration in the mammalian cochlea.

Keywords： inner ear     cochlea     hair cell     regeneration     Wnt     Notch     signaling pathways    

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Relationship between selenium concentration in child hair and the distribution of Kashin-Beck Disease

LI Shunjiang, YANG Linsheng, WANG Wuyi, LI Yonghua, LI Hairong, XIRAO Ruodeng

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 223-225 doi: 10.1007/s11684-007-0043-1

Abstract: focus of this study is to determine the relationship between selenium (Se) concentrations in child hairThe hair of children in typical KBD-affected areas and non-disease areas was collected, and its Se concentrationsThe Se concentrations in child hair were (0.13±0.04) and (0.18±0.07) µg/g respectively in KBD areas andIn areas supplemented with Se in Tibet, the Se concentration of hair in KBD- affected areas was higherThere is a close relationship between the Se concentrations in hair and KBD distribution.

Keywords： different     relationship     non-disease     selenium     KBD distribution    

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Identification and selection of resistance to

Lizhen ZHU, Jianying LI, Zhongping XU, Hakim MANGHWAR, Sijia LIANG, Suli LI, Muna ALARIQI, Shuangxia JIN, Xianlong ZHANG

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 2,   Pages 236-252 doi: 10.15302/J-FASE-2018223

Abstract: that okra shaped leaves reduced adult whitefly oviposition preference, while glabrous leaves and high hair

Keywords： Bemisia tabaci     Gossypium genotypes     gossypol     leaf hair density     leaf hair length    

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Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 8-27 doi: 10.15302/J-FASE-2018233

Abstract:

Pluripotent stem cells (PSCs) are characterized by their capacity for high self-renewal and multipledifferentiation potential and include embryonic stem cells, embryonic germ cells and induced PSCs.

Keywords： embryonic germ cells     embryonic stem cells     induced pluripotent stem cells     pigs     pluripotent stem cells    

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Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Frontiers of Medicine 2007, Volume 1, Issue 3,   Pages 294-298 doi: 10.1007/s11684-007-0056-9

Abstract: Although all normal tissue cells, including stem cells, are genetically homologous, variation in geneFor instance, chemotherapy usually leads to depression of bone marrow and hair loss.In normal adults, telomerase activation mainly presents in tissue stem cells and progenitor cells givingand only minorities of cells, designated as cancer stem cells, undergo processes analogous to the self-renewalThe results indicated that cancer stem cells show a higher level of enzyme activity than non-stem cells
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Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 34-47 doi: 10.1007/s11684-017-0606-8

Abstract: and antibody-producing B cells) achieve viral clearance and host recovery.Adaptive T and B cells maintain immunological memory and provide protection against subsequent infectionsRecent studies also shed light on the role of innate T-cells (MAIT cells, gd T cells, and NKT cells)We summarize the current knowledge on influenza-specific innate MAIT and gd T cells as well as adaptiveCD8+ and CD4+ T cells, and discuss how these responses can be harnessed by novel

Keywords： influenza     innate T cells     CD4+ and CD8+ T cells     vaccination    

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Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Frontiers of Agricultural Science and Engineering 2019, Volume 6, Issue 1,   Pages 28-32 doi: 10.15302/J-FASE-2018222

Abstract:

Primordial germ cells (PGCs) are regarded as unipotent cells that can produce only either spermatogoniaHowever, PGCs can be converted into the pluripotent state by first dedifferentiation to embryonic germ cellsand then by reprogramming to induce them to become pluripotent stem cells (iPSCs).These two stages can be completely implemented with mouse cells.

Keywords： pig     pluripotent stem cells     primordial germ cells     reprogramming    

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4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL in-1BBL cDNA sequence was constructed, and the plasmid was transfected into baby hamster kidney (BHK) cellsand murine muscle cells by means of lipofectin-mediated or naked plasmid DNA injection into the muscleThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferation

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

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Title Author Date Type Operation

Regeneration of hair cells in the mammalian vestibular system

Wenyan Li,Dan You,Yan Chen,Renjie Chai,Huawei Li

Journal Article

Behavioral methods for the functional assessment of hair cells in zebrafish

Qin Yang, Peng Sun, Shi Chen, Hongzhe Li, Fangyi Chen

Journal Article

MicroRNA-148b promotes proliferation of hair follicle cells by targeting

Wanbao YANG,Qinqun LI,Bo SU,Mei YU

Journal Article

Loss of liver kinase B1 causes planar polarity defects in cochlear hair cells in mice

Yuqin Men,Aizhen Zhang,Liwen Zhang,Yecheng Jin,Zhishuo Wang,Jing Zhao,Xiaolin Yu,Jian Zhang,Jiangang Gao

Journal Article

Apigenin alleviates neomycin-induced oxidative damage via the Nrf2 signaling pathway in cochlear haircells

Journal Article

Alternative splicing of inner-ear-expressed genes

Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu

Journal Article

is essential for the integrity of stereociliary rootlet in cochlear hair cells in mice

Yuqin Men, Xiujuan Li, Hailong Tu, Aizhen Zhang, Xiaolong Fu, Zhishuo Wang, Yecheng Jin, Congzhe Hou, Tingting Zhang, Sen Zhang, Yichen Zhou, Boqin Li, Jianfeng Li, Xiaoyang Sun, Haibo Wang, Jiangang Gao

Journal Article

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

Muhammad Waqas,Shasha Zhang,Zuhong He,Mingliang Tang,Renjie Chai

Journal Article

Relationship between selenium concentration in child hair and the distribution of Kashin-Beck Disease

LI Shunjiang, YANG Linsheng, WANG Wuyi, LI Yonghua, LI Hairong, XIRAO Ruodeng

Journal Article

Identification and selection of resistance to

Lizhen ZHU, Jianying LI, Zhongping XU, Hakim MANGHWAR, Sijia LIANG, Suli LI, Muna ALARIQI, Shuangxia JIN, Xianlong ZHANG

Journal Article

Porcine pluripotent stem cells: progress, challenges and prospects

Jianyong HAN, Yi-Liang MIAO, Jinlian HUA, Yan LI, Xue ZHANG, Jilong ZHOU, Na LI, Ying ZHANG, Jinying ZHANG, Zhonghua LIU

Journal Article

Determination of telomerase activity in stem cells and non-stem cells of breast cancer

LI Zhi, HE Yanli, ZHANG Jiahua, ZHANG Jinghui, HUANG Tao

Journal Article

Innate and adaptive T cells in influenza disease

Simone Nüssing, Sneha Sant, Marios Koutsakos, Kanta Subbarao, Thi H.O. Nguyen, Katherine Kedzierska

Journal Article

Reprogramming of the pig primordial germ cells into pluripotent stem cells: a brief review

Qijing LEI, Qin PAN, Shuai YU, Na LI, Shulin CHEN, Kuldip SIDHU, Jinlian HUA

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article